Randomized Clinical Study, Comparative of Parallel Groups, to Evaluate the Effectiveness of Three Preparations of Potassium Citrate in Producing an Increase in Urinary pH in Patients with a History of Kidney Stones

Background: A very strict control of urinary pH is recommended to maintain it between 5.5 and 6.2, preventing formation or recurrence crystals. Kidney stones are a common problem, with high rate recurrence, not altered by the success surgery. Medical treatment prevents recurrence. Potassium Citrate inhibits crystallization calcium salts. It influences calculogenesis increasing citrates alkalinizing urine. Purpose: evaluate similarity in effect three K citrate products, reference product Urocit® 10 mEq, from Laboratorios LETI S.A.V., mEq 15 on pH. Materials Methods: We carried out prospective, randomized study parallel groups. admitted female male patients history kidney evidence lithiasis (grit, microlithiasis) renal echosonogram. Laboratory assessments: urine, 24-hour pH, Calcium, uric acid, Phosphorus, Sodium, protein creatinine at times: start, day 7, 21, 30 treatment. Results: all products produced slight increase simple urine test no differences groups their logarithmically transformed means CI95, which did exceed range 80% 125%. Conclusions: Citrate, 7.5 LETI, dose daily equivalent Urocit®, its effects test.